Agaba Tab (artemisinin-piperaquine)
₦3,000.00
Artemisinin-piperaquine (also known as DHA/PPQ) is a combination medication used in the treatment of malaria. It combines dihydroartemisinin (DHA), derived from Artemisia annua, a traditional Chinese medicinal treatment for fever, with piperaquine, an antimalarial drug that remains in the body for up to 60 days
Artemisinin-piperaquine (also known as DHA/PPQ) is a combination medication used in the treatment of malaria. It combines dihydroartemisinin (DHA), derived from Artemisia annua, a traditional Chinese medicinal treatment for fever, with piperaquine, an antimalarial drug that remains in the body for up to 60 days. Here are some key details about this medication:
- Therapeutic Action: Artemisinin-piperaquine is an antimalarial drug used for the following purposes:
- Treatment of uncomplicated falciparum malaria.
- Treatment of uncomplicated malaria caused by other Plasmodium species when chloroquine cannot be used.
- Completion treatment following parenteral therapy for severe malaria.
- Forms and Strengths: It is available in co-formulated tablets containing dihydroartemisinin (DHA) and piperaquine (PPQ). There are several blister pack options:
- 20 mg DHA/160 mg PPQ tablets (blister pack of 3 tablets).
- 40 mg DHA/320 mg PPQ tablets (blister pack of 3, 6, 9, or 12 tablets)
- 62.5 mg DHA/375 mg PPQ tablets (blister pack of 4 tablets)
- Dosage and Duration:
- For children weighing 5 to < 25 kg: DHA (2.5 to 10 mg/kg daily) + PPQ (20 to 32 mg/kg daily).
- For children ≥ 25 kg and adults: DHA (2 to 10 mg/kg daily) + PPQ (16 to 27 mg/kg daily).
- Tablets are taken once daily for 3 days.
- Contraindications and Precautions:
- Avoid administering to patients with cardiac disorders (bradycardia, heart rhythm issues, congestive heart failure).
- Do not combine with drugs that prolong the QT interval (e.g., amiodarone, other antimalarials, antipsychotics).
- Use with caution in patients > 60 years or with renal/hepatic impairment.
- Possible adverse effects include cardiac disorders (QT prolongation, tachycardia), gastrointestinal disturbances, pruritus, hepatic disorders, joint/muscle pain.
- Monitor interactions with antiretrovirals and enzyme inducers
- Pregnancy and Breastfeeding: No contraindications
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